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In
cytology, although we receive samples from diverse areas we are able to
recognise precise criteria for malignancy.
· Epithelial cells which are normally cohesive become isolated · Cylindrical glandular cells become three dimensional groups instead of simple sheets · The relation between the nuclear size and the cytoplasm increases · The nuclear membrane becomes irregular · The nuclear chromatin becomes dense, clumped and irregular · The nucleolus can become prominent and irregular · Generally the size of the cell increases, however in certain lesions the cells may diminish in size · It is possible to find enormous differences in size and form between the cells, on the other hand certain cancer cells resemble so identically the normal cells that the identification of malignancy is extremely difficult .The
secretory properties of the cell may be transformed or intensified |
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Normal squamous epithelial cells. The cells and their nuclei are uniform and much of the same size. Glycogen is present which gives certain cytoplasm their slightly yellow colouring. | |||
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Malignant squamous epithelial cells. The background image shows polymorphonuclears and blood. The nuclei present important irregularities of size and form. The chromatin is clumped and thickened. The orange coloured cytoplasm denotes the presence of keratin. | |||
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Normal ciliated mucus secreting cylindrical cells. Note the simple single arrangement of the cells containing nuclei with fine even chromatin. | |||
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Malignant cylindrical cells. Here the cellular forms are extremely irregular and varied with nuclei containing thickened chromatin. | |||
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Dernière mise à
jour: le 31 janvier, 2004
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Pour en savoir plus: Riotton G, Christopherson WM: Cytologie de l'appareil génital féminin. Classification Histologique Internationale de Tumeurs, No.8, OMS, 1973. Takahashi: Color Atlas of Cancer Cytology. Geor Thieme Verlag, 1981.
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